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Ref #600 : Variation in amino acid transport along the rabbit small intestine. Mutual jejunal carriers of leucine and lysine
Author(s):
Munck LK, Munck BG.
Date:
1992
Reference Type:
Journal
Periodical:
Biochimica et Biophysica Acta, General Subjects
Issue:
1116
Volume:
2
Page range:
83 - 90
Keywords:
Absorption, Alanine, Amino-acids, Carriers, Ileum, Imino-acids, Jejunum, Leucine, Lysine, Man, Proline, Rabbits, Small-intestine, Taurine, Transport, Variation.
Abstract / Notes:
The jejuno-ileal variation of amino and imino acid transport across the brush-border membrane of intact rabbit small intestine was studied. For beta -alanine, leucine, lysine, 2-(methylamino)-isobutyrate (MeAIB), proline and D-glucose, the rates of transport at constant concentrations increased from very low values in the proximal jejunum to maximum values in the most distal 30 cm of the ileum. The apparent affinity constant for jejunal taurine transport is identical to that of the distal ileum, while the jejunal transport capacity was less than half. In the jejunum, as in the distal ileum, leucine and lysine share both sodium-dependent and Na-independent carriers. About 50% of the quantitative difference in transport capacity was accounted for by the absence of the beta -alanine carrier in the jejunum. The data indicate that gradients of transport along the small intestine reflect gradients of transport capacities rather than affinities. In comparison with the hamster, man and rat, the rabbit seems unique with respect to the location of transport maximum and the steepness of the gradient along the intestine601